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1

Pushing the Limits: Machine Preservation of the Liver as a Tool to Recondition High-Risk Grafts

Boteon, Yuri L., Afford, Simon C., Mergental, Hynek

Journal:

Current Transplantation Reports

Year:

2018

Language:

english

File:

PDF, 444 KB

english, 2018

2

Visualization of Acute Liver Damage Induced by Cycloheximide in Rats Using PET with [18F]FEDAC, a Radiotracer for Translocator Protein (18 kDa)

Hatori, Akiko, Yui, Joji, Xie, Lin, Yamasaki, Tomoteru, Kumata, Katsushi, Fujinaga, Masayuki, Wakizaka, Hidekatsu, Ogawa, Masanao, Nengaki, Nobuki, Kawamura, Kazunori, Zhang, Ming-Rong, Afford, Simon

Journal:

Year:

2014

Language:

english

File:

PDF, 12.76 MB

english, 2014

3

[BMJ Publishing Group Ltd Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018 - ()] Poster Presentation: Cancer Cell Biology - PO-120 Proline rich homeodomain protein is required for cholangiocarcinoma tumour growth

Jayaraman, PS, Lee, KY, Kitchen, P, Clark, D, Lertsuwan, J, Sawasdichai, A, Oltean, S, Satayavivad, J, Simon Afford, SA, Gaston, K

Year:

2018

Language:

english

File:

PDF, 71 KB

english, 2018

4

An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells

Boteon, Yuri L., Wallace, Lorraine, Boteon, Amanda P. C. S., Mirza, Darius F., Mergental, Hynek, Bhogal, Ricky H., Afford, Simon, Vinciguerra, Manlio

Journal:

Year:

2018

Language:

english

File:

PDF, 18.26 MB

english, 2018

5

CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism

Lertsuwan, Jomnarong, Lertsuwan, Kornkamon, Sawasdichai, Anyaporn, Tasnawijitwong, Nathapol, Lee, Ka, Kitchen, Philip, Afford, Simon, Gaston, Kevin, Jayaraman, Padma-Sheela, Satayavivad, Jutamaad

Journal:

Year:

2018

Language:

english

File:

PDF, 4.26 MB

english, 2018

6

Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis

Afford, Simon C., Fisher, Neil C., Neil, Desley A. H., Fear, Janine, Brun, Paoula, Hubscher, Stefan G., Adams, David H.

Journal:

The Journal of Pathology

Year:

1998

Language:

english

File:

PDF, 1.44 MB

english, 1998

7

Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion

Edward B. Alabraba, Vincent Lai, Louis Boon, Stephen J. Wigmore, David H. Adams, Simon C. Afford

Journal:

Year:

2008

Language:

english

File:

PDF, 1.43 MB

english, 2008

8

Expression and function of CXC and CC chemokines in human malignant liver tumors: A role for human monokine induced by γ-interferon in lymphocyte recruitment to hepatocellular carcinoma

Khong F. Yoong, Simon C. Afford, Rebecca Jones, Pav Aujla, Shixin Qin, Kate Price, Stefan G. Hubscher, David H. Adams

Journal:

Year:

1999

Language:

english

File:

PDF, 712 KB

english, 1999

9

Blockade of janus kinase 2 signaling ameliorates mouse liver damage due to ischemia and reperfusion

Ricky H. Bhogal, Simon C. Afford

Journal:

Liver Transplantation

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

10

Reply: Blockade of Janus kinase 2 signaling ameliorates mouse liver damage due to ischemia and reperfusion

Ricky Harminder Bhogal, Simon C. Afford

Journal:

Liver Transplantation

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

11

Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation

Ricky Harminder Bhogal, Stuart M. Curbishley, Christopher J. Weston, David H. Adams, Simon C. Afford

Journal:

Liver Transplantation

Year:

2010

Language:

english

File:

PDF, 550 KB

english, 2010

12

Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model

Ricky H. Bhogal, Simon C. Afford

Journal:

Liver Transplantation

Year:

2010

Language:

english

File:

PDF, 41 KB

english, 2010

13

Hepatic liver ischemia/reperfusion injury: Processes in inflammatory networks – A review

Ricky H. Bhogal, Rupesh Sutaria, Simon C. Afford

Journal:

Liver Transplantation

Year:

2011

Language:

english

File:

PDF, 40 KB

english, 2011

14

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: Mechanisms and Effects on liver regeneration

Ricky Harminder Bhogal, Barnaby Thomas Francis Stephenson, Simon Charles Afford

Journal:

Liver Transplantation

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

15

Apoptosis in the human liver during allograft rejection and end-stage liver disease

Dr Simon C. Afford, Stefan Hubscher, Alastair J. Strain, David H. Adams, James M. Neuberger

Journal:

The Journal of Pathology

Year:

1995

Language:

english

File:

PDF, 716 KB

english, 1995

16

Effect of peritransplant FTY720 alone or in combination with post-transplant tacrolimus in a rat model of cardiac allotransplantation

M. Xu, Jacques Pirenne, Efstathios A Antoniou, Simon C Afford, Milbhor D'Silva, P. McMaster

Journal:

Transplant International

Year:

1998

Language:

english

File:

PDF, 191 KB

english, 1998

17

Effect of peritransplant FTY720 alone or in combination with post-transplant tacrolimus in a rat model of cardiac allotransplantation

Min Xu, Jacques Pirenne, Efstathios A Antoniou, Simon C Afford, Milbhor D'Silva, Paul McMaster

Journal:

Transplant International

Year:

1998

Language:

english

File:

PDF, 629 KB

english, 1998

18

Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes

Ricky H. Bhogal, Simon C. Afford

Journal:

Liver International

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

19

Gene therapy for hepatocellular carcinoma—teaching old dogs new tricks

Simon C. Afford, Lawrence S. Young

Journal:

Year:

2001

Language:

english

File:

PDF, 42 KB

english, 2001

20

CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2

Jalal Ahmed-Choudhury, Kevin T. Williams, Lawrence S. Young, David H. Adams, Simon C. Afford

Journal:

Cellular Signalling

Year:

2006

Language:

english

File:

PDF, 321 KB

english, 2006

21

Variable responses of small and large human hepatocytes to hypoxia and hypoxia/reoxygenation (H–R)

Ricky H. Bhogal, Christopher J. Weston, Stuart M. Curbishley, Anand N. Bhatt, David H. Adams, Simon C. Afford

Journal:

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

22

A new approach to isolation and culture of human Kupffer cells

Edward B. Alabraba, Stuart M. Curbishley, Wai K. Lai, Stephen J. Wigmore, David H. Adams, Simon C. Afford

Journal:

Journal of Immunological Methods

Year:

2007

Language:

english

File:

PDF, 378 KB

english, 2007

23

An evaluation of four methods for the measurement of elastase activity

David H. McGillivray, David Burnett, Simon C. Afford, Robert A. Stockley

Journal:

Clinica Chimica Acta

Year:

1981

Language:

english

File:

PDF, 359 KB

english, 1981

24

The effect of inducing agents on the numbers of interphase fibrillar centers in the U937 promonocytic cell line

Stephen Edwards, Simon Afford, John Crocker

Journal:

Experimental Cell Research

Year:

1991

Language:

english

File:

PDF, 2.16 MB

english, 1991

25

Selection of tumour specific promoters for adenoviral gene therapy of cholangiocarcinoma

Michael Lie-A-Ling, Conny T. Bakker, Tanja Deurholt, Ruurdtje Hoekstra, John G. Wesseling, Simon C. Afford, Piter J. Bosma

Journal:

Journal of Hepatology

Year:

2006

Language:

english

File:

PDF, 313 KB

english, 2006

26

A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration

Garrick K. Wilson, Claire L. Brimacombe, Ian A. Rowe, Gary M. Reynolds, Nicola F. Fletcher, Zania Stamataki, Ricky H. Bhogal, Maria L. Simões, Margaret Ashcroft, Simon C. Afford, Ragai R. Mitry, Anil

Journal:

Journal of Hepatology

Year:

2012

Language:

english

File:

PDF, 1009 KB

english, 2012

27

Hepatic Stellate Cells Express the Low Affinity Nerve Growth Factor Receptor p75 and Undergo Apoptosis in Response to Nerve Growth Factor Stimulation

Nathan Trim, Sue Morgan, Martyn Evans, Razao Issa, David Fine, Simon Afford, Bridget Wilkins, John Iredale

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 1.24 MB

english, 2000

28

Fas/Fas Ligand Interaction in Human Colorectal Hepatic Metastases: A Mechanism of Hepatocyte Destruction to Facilitate Local Tumor Invasion

Khong F. Yoong, Simon C. Afford, Satinder Randhawa, Stefan G. Hubscher, David H. Adams

Journal:

The American Journal of Pathology

Year:

1999

Language:

english

File:

PDF, 2.77 MB

english, 1999

29

Ontogeny of Hepatocyte Growth Factor (HGF) and Its Receptor (c-met) in Human Placenta: Reduced HGF Expression in Intrauterine Growth Restriction

David A. Somerset, Xiao-Feng Li, Simon Afford, Alastair J. Strain, Asif Ahmed, Rajabant K. Sangha, Martin J. Whittle, Mark D. Kilby

Journal:

The American Journal of Pathology

Year:

1998

Language:

english

File:

PDF, 1.77 MB

english, 1998

30

Pro-inflammatory stimuli and not reactive oxygen species regulate adhesion molecule expression upon human liver sinusoidal endothelial cells during hepatic ischaemia-reperfusion injury

Ricky Bhogal, David Adams, Simon Afford

Journal:

International Journal of Surgery

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

31

Cathepsin B synthesis by the HL60 promyelocytic cell line: effects of stimulating agents and anti-inflammatory compounds

David Burnett, John Crocker, Simon C. Afford, Christopher M. Bunce, Geoffrey Brown, Robert A. Stockley

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1986

Language:

english

File:

PDF, 763 KB

english, 1986

32

Fn14 is expressed on neoplastic cholangiocytes in intrahepatic cholangiocarcinoma and promotes necrosis after interaction with TWEAK

Stephenson, Barnaby, Humphreys, Elizabeth, Burkly, Linda, Adams, David, Afford, Simon

Journal:

Year:

2013

Language:

english

File:

PDF, 42 KB

english, 2013

33

Shotgun proteomics: Identification of unique protein profiles of apoptotic bodies from biliary epithelial cells

Lleo, Ana, Zhang, Weici, McDonald, W. Hayes, Seeley, Erin H., Leung, Patrick S.C., Coppel, Ross L., Ansari, Aftab A., Adams, David H., Afford, Simon, Invernizzi, Pietro, Gershwin, M. Eric

Journal:

Year:

2014

Language:

english

File:

PDF, 679 KB

english, 2014

34

Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis

Afford, Simon C., Humphreys, Elizabeth H., Reid, Danielle T., Russell, Clare L., Banz, Vanessa M., Oo, Ye, Vo, Tina, Jenne, Craig, Adams, David H., Eksteen, Bertus

Journal:

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

35

Quantitative assessment of the cell surface proteome to identify novel therapeutic targets in cholangiocarcinoma

Stephenson, Barney, Shimwell, Neil, Humphreys, Elizabeth, Ward, Douglas, Adams, David, Martin, Ashley, Afford, Simon

Journal:

Year:

2015

Language:

english

File:

PDF, 52 KB

english, 2015

36

Regulation of α 1 -Antitrypsin Synthesis by Granulocyte Macrophage Colony-Stimulating Factor in the U937 Promonocytic Cell Line

AFFORD, Simon C., BURNETT, David, STOCKLEY, Robert A.

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1992

File:

PDF, 1.66 MB

1992

37

Qualitative Studies of Lung Lavage α 1 -Proteinase Inhibitor

STOCKLEY, Robert A., AFFORD, Simon C.

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1984

Language:

english

File:

PDF, 1.20 MB

english, 1984

38

The Assessment of α 1 Proteinase Inhibitor Form and Function in Lung Lavage Fluid from Healthy Subjects

AFFORD, Simon C., BURNETT, David, CAMPBELL, Edward J., CURY, James Davis, STOCKLEY, Robert A.

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1988

File:

PDF, 1.68 MB

1988

39

Autophagy

Bhogal, Ricky H., Weston, Christopher J., Curbishley, Stuart M., Adams, David H., Afford, Simon C.

Journal:

Year:

2012

Language:

english

File:

PDF, 3.29 MB

english, 2012

40

The Electrophoretic Mobility of α 1 -Proteinase Inhibitor: Effects of Proteolysis and Cigarette Smoke

STOCKLEY, Robert A., AFFORD, Simon C., BURNETT, David

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1982

Language:

english

File:

PDF, 1.03 MB

english, 1982

41

Immune-Mediated Liver Injury

Eksteen, Bertus, Afford, Simon, Wigmore, Stephen, Holt, Andrew, Adams, David

Journal:

Seminars in Liver Disease

Year:

2007

Language:

english

File:

PDF, 458 KB

english, 2007

42

Extracellular Proteolysis of Fibronectin by Neutrophils: Characterization and the Effects of Recombinant Cytokines

Chamba, Anita, Afford, Simon C., Stockley, Robert A., Burnett, David

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

1991

Language:

english

File:

PDF, 1006 KB

english, 1991

43

CD40 INDUCED Fas-L EXPRESSION MAY CONTRIBUTE TO THE LOSS OF BILE DUCTS BY APOPTOSIS IN CHRONIC ALLOGRAFT REJECTION.

Afford, Simon C., Rhandawa, Satinder, Yooster, Janine, Young, Lawrence S., Adams, David H.

Journal:

Transplantation Journal

Year:

2000

File:

PDF, 1.60 MB

2000

44

The Interaction of Cigarette Smoke Solution with α 1 -Antitrypsin: Effect on Inhibitory Capacity, Electrophoretic Mobility and Immunological Measurement

Stockley, Robert A., Afford, Simon C.

Journal:

Clinical Science

Year:

1983

Language:

english

File:

PDF, 652 KB

english, 1983

45

Evidence for lipid-associated serine proteases and metalloproteases in human bronchoalveolar lavage fluid

Burnett, David, Afford, Simon C., Campbell, Edward J., Rios-Mollineda, Raul A., Buttle, David J., Stockley, Robert A.

Journal:

Clinical Science

Year:

1988

Language:

english

File:

PDF, 658 KB

english, 1988

46

Proof of concept: liver splitting during normothermic machine perfusion

Stephenson, Barney T F, Bonney, Glenn K, Laing, Richard W, Bhogal, Ricky H, Marcon, Francesca, Neil, Desley A H, Perera, M Thamara P R, Afford, Simon C, Mergental, Hynek, Mirza, Darius F

Journal:

Journal of Surgical Case Reports

Year:

2018

Language:

english

File:

PDF, 761 KB

english, 2018

47

Primary and Malignant Cholangiocytes Undergo CD40 Mediated Fas Dependent Apoptosis, but Are Insensitive to Direct Activation with Exogenous Fas Ligand

Humphreys, Elizabeth H., Williams, Kevin T., Adams, David H., Afford, Simon C., Blagosklonny, Mikhail V.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

48

Induction of Bcl-2 Expression by Hepatitis B Virus Pre-S2 Mutant Large Surface Protein Resistance to 5-Fluorouracil Treatment in Huh-7 Cells

Hung, Jui-Hsiang, Teng, Yen-Ni, Wang, Lily Hui-Ching, Su, Ih-Jen, Wang, Clay C. C., Huang, Wenya, Lee, Kuan-Han, Lu, Kuan-Ying, Wang, Lyu-Han, Afford, Simon

Journal:

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

49

Activation of CD40 with Platelet Derived CD154 Promotes Reactive Oxygen Species Dependent Death of Human Hepatocytes during Hypoxia and Reoxygenation

Bhogal, Ricky H., Weston, Christopher J., Curbishley, Stuart M., Adams, David H., Afford, Simon C., Langsley, Gordon

Journal:

Year:

2012

Language:

english

File:

PDF, 1.81 MB

english, 2012

50

Pertussis Toxin, an Inhibitor of Gαi PCR, Inhibits Bile Acid- and Cytokine-Induced Apoptosis in Primary Rat Hepatocytes

Karimian, Golnar, Buist-Homan, Manon, Faber, Klaas Nico, Moshage, Han, Afford, Simon

Journal:

Year:

2012

Language:

english

File:

PDF, 572 KB

english, 2012